Police say emergency services were called to Hawk Hill Road shortly after 7.30am yesterday following reports the Isuzu truck travelling north had crashed off the road.
The driver, a 56-year-old Payneham South man, was found dead at the scene, police say. He was the sole occupant of the vehicle.
Police announced late on Tuesday that Major Crash investigators would be examining the circumstances surrounding the crash.
It is the first death recorded on South Australian roads this year, compared to five at the same point last year.
There were 94 fatal crashes in South Australia in 2021, resulting in 99 fatalities, according to SAPOL data.
There have already been 18 crashes resulting in serious injury within the first two weeks of 2022.