The flight is scheduled to touch down at Adelaide Airport at 3.44pm.
It will be the first time an Airbus A350-900 has landed in Australia, with airport managing director Mark Young describing the plane as “one of the world’s most technologically advanced twin-engine aircraft”.
Qatar also flies to Sydney, Melbourne and Perth.
Minister Bignell said the airline’s expansion into Adelaide would inject about $41 million into South Australia’s economy and create 228 jobs across the state.
“Not only will the Qatar Airways flights bring tourists to South Australia, but the return flights present a chance to fill the A350-900’s cargo with as much as 80 tonnes of premium South Australian produce,” he said.